Introduction

Research

The Molecular Genetics group is involved in fundamental research related to the structure, regulation and maintenance of the genetic material in various organisms ranging from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae to human cells. Both DNA and RNA related processes are studied.

News

Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin
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Henriëtte L. Lanz, Rhyenne M.E. Zimmerman, Jacob Brouwer, Mathieu H.M. Noteborn and Claude Backendorf in CCDis.

Mitotic catastrophe is an oncosuppressive mechanism that senses mitotic failure leading to cell death or senescence. As such it protects against aneuploidy and genetic instability and its induction in cancer cells by exogenous agents is currently seen as a promising therapeutic endpoint.

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Article published
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Now online in Nature Communications our first studies on the action and interplay of the chromatin proteins Alba1 and Alba1 from the archaeon Sulfolobus solfataricus.

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Article published
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Now online in Nucleic Acids Research our first studies on the chromatin proteins Sul7 and Cren7 from the archaeon Sulfolobus solfataricus.

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In de media: Remus Dame in De Groene Amsterdammer

De Groene Amsterdammer presenteert de tien grootste doorbraken in de wetenschap. 89 bèta-wetenschappers beantwoordden vragen over de belangrijkste ontwikkelingen in hun vakgebied, de doorbraken die ze verwachten, en de waarde van hun wetenschap voor de samenleving.

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