2010

Marques-Gallego, P., den Dulk, H., Backendorf, C., Brouwer, J., Reedijk, J., Burke, J.F. , Accurate non-invasive image-based cytotoxicity assays for cultured cells, Bmc Biotechnology, vol. 10, pp. -.

2009

Marques-Gallego, P., Kalayda, G.V., Jaehde, U., den Dulk, H., Brouwer, J., Reedijk, J. , Cellular accumulation and DNA platination of two new platinum(II) anticancer compounds based on anthracene derivatives as carrier ligands, Journal of Inorganic Biochemistry, vol. 103, no. 5, pp. 791-796.

Marques-Gallego, P., den Dulk, H., Brouwer, J., Tanase, S., Mutikainen, I, Turpeinen, U., Reedijk, J. , Cytotoxic activity and cellular processing in human ovarian carcinoma cell lines of a new platinum(II) compound containing a fluorescent substituted propylene diamine ligand, Biochemical Pharmacology, vol. 78, no. 4, pp. 365-373.

2008

den Dulk, B., van Eijk, P., de Ruijter, M., Brandsma, J.A., Brouwer, J. , The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4, DNA Repair, vol. 7, no. 6, pp. 858-868.

Marques-Gallego, P., den Dulk, H., Brouwer, J., Kooijman, H., Spek, A.L., Roubeau, O., Teat, S.J., Reedijk, J. , Synthesis, Crystal Structure, Studies in Solution and Cytotoxicity of Two New Fluorescent Platinum(II) Compounds Containing Anthracene Derivatives as a Carrier Ligand, Inorganic Chemistry, vol. 47, no. 23, pp. 11171-11179.

2007

Garza-Ortiz, A., den Dulk, H., Brouwer, J., Kooijman, H., Spek, A.L., Reedijk, J. , The synthesis, chemical and biological properties of dichlorido(azpy)gold(III) chloride (azpy=2-(phenylazo)pyridine) and the gold-induced conversion of the azpy ligand to the chloride of the novel tricyclic pyrido[2,1-c][1,2,4]benzotriazin-11-ium cation, Journal of Inorganic Biochemistry, vol. 101, no. 11-12, pp. 1922-1930.

Li, Q.L., Ye, K., Blad, C.C., den Dulk, H., Brouwer, J., IJzerman, A.P., Beukers, M.W. , ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor, Journal of Pharmacology and Experimental Therapeutics, vol. 320, no. 2, pp. 637-645.

2006

van Rijt, S., van Zutphen, S., den Dulk, H., Brouwer, J., Reedijk, J. , Structure-activity relationship studies for three new asymmetric cis-platinum(II) aminoethanol-based complexes, Inorganica Chimica Acta, vol. 359, no. 12, pp. 4125-4129.

den Dulk, B., Sun, S.M., de Ruijter, M., Brandsma, J.A., Brouwer, J. , Rad33, a new factor involved in nucleotide excision repair in Saccharomyces cerevisae, DNA Repair, vol. 5, no. 6, pp. 683-692.

van Zutphen, S., Pantoja, E., Soriano, R., Soro, C., Tooke, D.M., Spek, A.L., den Dulk, H., Brouwer, J., Reedijk, J. , New antitumour active platinum compounds containing carboxylate ligands in trans geometry: synthesis, crystal structure and biological activity, Dalton Transactions, no. 8, pp. 1020-1023.

2005

van Zutphen, S., Stone, E.A., van Rijt, S., Robillard, M.S., van der Marel, G.A., Overkleeft, H.S., den Dulk, H., Brouwer, J., Reedijk, J. , Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods, Journal of Inorganic Biochemistry, vol. 99, no. 10, pp. 2032-2038.

Backendorf, C., de Wit, J., van Oosten, M., Stout, G.J., Mitchell, J.R., Borgstein, A.M., van der Horst, G.T., de Gruijl, F.R., Brouwer, J., Mullenders, L.H.F., Hoeijmakers, J.H.J. , Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice, DNA Repair, vol. 4, no. 11, pp. 1325-1336.

den Dulk, B., Brandsma, J.A., Brouwer, J. , The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae, Molecular Microbiology, vol. 56, no. 6, pp. 1518-1526.

Duquesne, A.E., de Ruijter, M., Brouwer, J., Drijfhout, J.W., Nabuurs, S.B., Spronk, C.A.E.M., Vuister, G.W., Ubbink, M., Canters, G.W. , Solution structure of the second PDZ domain of the neuronal adaptor X11 alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase, Journal of Biomolecular Nmr, vol. 32, no. 3, pp. 209-218.

2004

Beukers, M.W., van Oppenraaij, J., van der Hoorn, P.P.W., Blad, C.C., den Dulk, H., Brouwer, J., IJzerman, A.P. , Random mutagenesis of the human adenosine A(2B) receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations, Molecular Pharmacology, vol. 65, no. 3, pp. 702-710.

Jansen, B.A.J., Wielaard, P., Kalayda, G.V., Ferrari, M., Molenaar, C., Tanke, H.J., Brouwer, J., Reedijk, J. , Dinuclear platinum complexes with N,N '-bis(aminoalkyl)-1,4-diaminoanthraquinones as linking ligands. Part I. Synthesis, cytotoxicity, and cellular studies in A2780 human ovarian carcinoma cells, Journal of Biological Inorganic Chemistry, vol. 9, no. 4, pp. 403-413.

van Waardenburg, R.C.A., de Jong, L.A., van Delft, F., van Eijndhoven, M.A.J., Bohlander, M., Bjornsti, M.A., Brouwer, J., Schellens, J.H.M. , Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons, Molecular Cancer Therapeutics, vol. 3, no. 4, pp. 393-402.

2003

Brouwer, E., Havenga, M., de Leeuw, B., Dirven, C., Hoeben, R., Smitt, P.S. , Adenoviral vectors for gene therapy of malignant glioma with improved cell entry, Molecular Therapy, vol. 7, no. 5, pp. S354-S354.

Belo, A. I, de Ruijter, T., den Dulk, H., Tijsterman, M., Mullenders, L., Brouwer, J. , The contribution of Pol Zeta, Rev1p and Pol Eta in UV induced mutagenesis in Saccharomyces cerevisiae, Yeast, vol. 20, pp. S90-S90.

Schenk, P.W., Wiemer, E.A., Brok, M., Boersma, A.W., Brandsma, J.A., Den Dulk, H., Burger, H., Stoter, G., Brouwer, J., Nooter, K. , Drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: Identification of a novel component involved in cisplatin/doxorubicin induced cell death., Clinical Cancer Research, vol. 9, no. 16, pp. 6247S-6247S.

Schenk, P.W., Brok, M., Boersma, A.W.M., Brandsma, J.A., Den Dulk, H., Burger, H., Stoter, G., Brouwer, J., Nooter, K. , Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin- and doxorubicin-provoked cell kill, Molecular Pharmacology, vol. 64, no. 2, pp. 259-268.

van Zutphen, S., Robillard, M.S., van der Marel, G.A., Overkleeft, H.S., den Dulk, H., Brouwer, J., Reedijk, J. , Extending solid-phase methods in inorganic synthesis: the first dinuclear platinum complex synthesised via the solid phase, Chemical Communications, no. 5, pp. 634-635.

2002

Jansen, B.A.J., Wielaard, P., den Dulk, H., Brouwer, J., Reedijk, J. , Oxa-aza crown ethers as ligands for mixed-ligand cisplatin derivatives and dinuclear platinum anticancer drugs, European Journal of Inorganic Chemistry, no. 9, pp. 2375-2379.

Schenk, P.W., Boersma, A.W.M., Brok, M., Brandsma, J.A., den Dulk, H., Burger, H., Brouwer, J., Stoter, G., Nooter, K. , Mechanisms of cisplatin resistance - role of yeast SKY1 and its human homologue SRPK1, European Journal of Cancer, vol. 38, pp. S15-S15.

Gonzalez-Barrera, S., Prado, F., Verhage, R., Brouwer, J., Aguilera, A. , Defective nucleotide excision repair in yeast hpr1 and tho2 mutants, Nucleic Acids Research, vol. 30, no. 10, pp. 2193-2201.

Jaap Brouwer teaches or supervises the following courses:

• Project A (LB1181)
• Moleculaire celbiologie (LB2091)
• Molecular defects in human diseases (LB2172)
• Gene-Expression (LM3061)
• Transcriptome & Proteome Analysis (LM3131)

For more information on courses and internships have a look at the education section.