Jaap Brouwer, Prof. Dr.
- Position:
- Scientific Director
- Research area:
- Telephone number
- +31 (0)71 527 4755
- E-mail address
- brouwer@chem.leidenuniv.nl
- Faculty/Unit
- Faculty of Science, Leiden Institute of Chemistry, Molecular Genetics
- Office address
- Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber 0.0.16
- 2010
Accurate non-invasive image-based cytotoxicity assays for cultured cells,
Bmc Biotechnology, vol. 10, pp. -.
- 2009
Cellular accumulation and DNA platination of two new platinum(II) anticancer compounds based on anthracene derivatives as carrier ligands,
Journal of Inorganic Biochemistry, vol. 103, no. 5, pp. 791-796.
Cytotoxic activity and cellular processing in human ovarian carcinoma cell lines of a new platinum(II) compound containing a fluorescent substituted propylene diamine ligand,
Biochemical Pharmacology, vol. 78, no. 4, pp. 365-373.
- 2008
The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4,
DNA Repair, vol. 7, no. 6, pp. 858-868.
Synthesis, Crystal Structure, Studies in Solution and Cytotoxicity of Two New Fluorescent Platinum(II) Compounds Containing Anthracene Derivatives as a Carrier Ligand,
Inorganic Chemistry, vol. 47, no. 23, pp. 11171-11179.
- 2007
The synthesis, chemical and biological properties of dichlorido(azpy)gold(III) chloride (azpy=2-(phenylazo)pyridine) and the gold-induced conversion of the azpy ligand to the chloride of the novel tricyclic pyrido[2,1-c][1,2,4]benzotriazin-11-ium cation,
Journal of Inorganic Biochemistry, vol. 101, no. 11-12, pp. 1922-1930.
ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor,
Journal of Pharmacology and Experimental Therapeutics, vol. 320, no. 2, pp. 637-645.
- 2006
Structure-activity relationship studies for three new asymmetric cis-platinum(II) aminoethanol-based complexes,
Inorganica Chimica Acta, vol. 359, no. 12, pp. 4125-4129.
Rad33, a new factor involved in nucleotide excision repair in Saccharomyces cerevisae,
DNA Repair, vol. 5, no. 6, pp. 683-692.
New antitumour active platinum compounds containing carboxylate ligands in trans geometry: synthesis, crystal structure and biological activity,
Dalton Transactions, no. 8, pp. 1020-1023.
- 2005
Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods,
Journal of Inorganic Biochemistry, vol. 99, no. 10, pp. 2032-2038.
Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice,
DNA Repair, vol. 4, no. 11, pp. 1325-1336.
The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae,
Molecular Microbiology, vol. 56, no. 6, pp. 1518-1526.
Solution structure of the second PDZ domain of the neuronal adaptor X11 alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase,
Journal of Biomolecular Nmr, vol. 32, no. 3, pp. 209-218.
- 2004
Random mutagenesis of the human adenosine A(2B) receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations,
Molecular Pharmacology, vol. 65, no. 3, pp. 702-710.
Dinuclear platinum complexes with N,N '-bis(aminoalkyl)-1,4-diaminoanthraquinones as linking ligands. Part I. Synthesis, cytotoxicity, and cellular studies in A2780 human ovarian carcinoma cells,
Journal of Biological Inorganic Chemistry, vol. 9, no. 4, pp. 403-413.
Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons,
Molecular Cancer Therapeutics, vol. 3, no. 4, pp. 393-402.
- 2003
Adenoviral vectors for gene therapy of malignant glioma with improved cell entry,
Molecular Therapy, vol. 7, no. 5, pp. S354-S354.
The contribution of Pol Zeta, Rev1p and Pol Eta in UV induced mutagenesis in Saccharomyces cerevisiae,
Yeast, vol. 20, pp. S90-S90.
Drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: Identification of a novel component involved in cisplatin/doxorubicin induced cell death.,
Clinical Cancer Research, vol. 9, no. 16, pp. 6247S-6247S.
Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin- and doxorubicin-provoked cell kill,
Molecular Pharmacology, vol. 64, no. 2, pp. 259-268.
Extending solid-phase methods in inorganic synthesis: the first dinuclear platinum complex synthesised via the solid phase,
Chemical Communications, no. 5, pp. 634-635.
- 2002
Oxa-aza crown ethers as ligands for mixed-ligand cisplatin derivatives and dinuclear platinum anticancer drugs,
European Journal of Inorganic Chemistry, no. 9, pp. 2375-2379.
Mechanisms of cisplatin resistance - role of yeast SKY1 and its human homologue SRPK1,
European Journal of Cancer, vol. 38, pp. S15-S15.
Defective nucleotide excision repair in yeast hpr1 and tho2 mutants,
Nucleic Acids Research, vol. 30, no. 10, pp. 2193-2201.
Jaap Brouwer teaches or supervises the following courses:
- Project A (LB1181)
- Moleculaire celbiologie (LB2091)
- Molecular defects in human diseases (LB2172)
- Gene-Expression (LM3061)
- Transcriptome & Proteome Analysis (LM3131)
For more information on courses and internships have a look at the education section.


