Mathieu Noteborn, Prof. Dr.
- Position:
- Professor of Biological Chemistry
- Research area:
- Telephone number
- +31 (0)71 527 4544
- E-mail address
- m.noteborn@chem.leidenuniv.nl
- Faculty/Unit
- Faculty of Science, Leiden Institute of Chemistry, Molecular Genetics
- Office address
- Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber 0.0.17
Biography
Sinds mijn middelbare schooltijd ben ik geboeid door plaatjes van cellulaire structuren en raakte tijdens mijn studie geinteresseerd in de genetische regulatie van bio-moleculaire processen. Geprogrammeerd doodgaan van cellen in een levend organisme, apoptose, is een van de belangrijkste levensprocessen. Verstoorde apoptoseroutes liggen ten grondslag aan een groot aantal ziektebeelden, zoals Alzheimer, depressie, diabetes, kanker en reuma. Interacties tussen bio-moleculen en tussen wetenschappers vormen mijn grootste inspiratiebronnen voor mijn biologisch-chemisch onderzoek, dat naar ik hoop een bijdrage zal leveren aan de ontwikkeling van nieuwe en verbeterde medicijnen.
- 2012
Development and application of an in vitro apoptin kinase assay,
Analytical Biochemistry, vol. 421, no. 1, pp. 68-74.
- 2011
Stem-loop structures can effectively substitute for an RNA pseudoknot in -1 ribosomal frameshifting,
Nucleic acids research, vol. 39, no. 20, pp. 8952-9.
PTD4-apoptin protein and dacarbazine show a synergistic antitumor effect on B16-F1 melanoma in vitro and in vivo,
European journal of pharmacology, vol. 654, no. 1, pp. 17-25.
- 2010
Anticancer genes: inducers of tumour-specific cell death signalling,
Trends in Molecular Medicine, vol. 16, no. 2, pp. 88-96.
Apoptin Enhances Radiation-Induced Cell Death in Poorly Responding Head and Neck Squamous Cell Carcinoma Cells,
Basic & Clinical Pharmacology & Toxicology, vol. 106, no. 2, pp. 130-134.
Anticancer genes: inducers of tumour-specific cell death signalling,
Trends in Molecular Medicine, vol. 16, no. 2, pp. 88-96.
Stimulation of ribosomal frameshifting by antisense LNA,
Nucleic Acids Research, vol. 38, no. 22, pp. 8277-8283.
- 2009
PTD4-apoptin protein therapy inhibits tumor growth in vivo,
International Journal of Cancer, vol. 124, no. 12, pp. 2973-2981.
A mouse model for oral squamous cell carcinoma,
Journal of Molecular Histology, vol. 40, no. 3, pp. 177-181.
Family at last: highlights of the first international meeting on proteins killing tumour cells,
Cell Death and Differentiation, vol. 16, no. 1, pp. 184-186.
Family at last: highlights of the first international meeting on proteins killing tumour cells,
Cell Death and Differentiation, vol. 16, no. 1, pp. 184-186.
Proteins selectively killing tumor cells,
European Journal of Pharmacology, vol. 625, no. 1-3, pp. 165-173.
Apoptin senses transformation-related nuclear transfer of SV40.,
Proteins killing tumour cells, vol. 1, Kerala, Research Signpost, pp. 179-190.
Apoptosis and cancer closely linked,
Proteins killing tumour cells, Kerala, Research Signpost, pp. 1-18.
Apoptosis-Inducing Proteins in Chicken Anemia Virus and TT Virus,
Tt Viruses - the Still Elusive Human Pathogens, vol. 331, pp. 131-149.
CRM197-targeted gene delivery to brain tumors,
Proteins killing tumour cells, Kerala, Research Signpost, pp. 219-244.
Preclinical studies on apoptin unravels its specific anticancer therapy potential,
Proteins killing tumour cells, Kerala, Research Signpost, pp. 191-206.
- 2008
Apoptin induces apoptosis in an oral cancer mouse model,
Cancer Biology & Therapy, vol. 7, no. 9, pp. 1370-1375.
Apoptin: Therapeutic potential of an early sensor of carcinogenic transformation,
Annual Review of Pharmacology and Toxicology, vol. 48, pp. 143-169.
- 2007
Viral protein apoptin as a molecular tool and therapeutic bullet: implications for cancer control,
Future Virology, vol. 2, no. 5, pp. 519-527.
Viral elements sense tumorigenic processes: Approaching selective cancer therapy,
Mini-Reviews in Medicinal Chemistry, vol. 7, no. 11, pp. 1155-1165.
Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor,
Cancer Gene Therapy, vol. 14, no. 1, pp. 66-73.
Additive cytotoxic effect of apoptin and chemotherapeutic agents paclitaxel and etoposide on human tumour cells,
Basic & Clinical Pharmacology & Toxicology, vol. 100, no. 2, pp. 127-131.
- 2006
Fibroblast-like synoviocytes from patients with rheumatoid arthritis are more sensitive to apoptosis induced by the viral protein, apoptin, than fibroblast-like synoviocytes from trauma patients,
Clinical and Experimental Rheumatology, vol. 24, no. 2, pp. 142-147.
- 2005
Relevance of apoptin's integrity for its functional behavior,
Journal of Virology, vol. 79, no. 2, pp. 1337-1338.
Mathieu Noteborn teaches or supervises the following courses:
- Project A (LB1181)
- Project B (LB1191)
- Moleculaire genetica 2 (LB2071)
- Transcriptome & Proteome Analysis (LM3131)
For more information on courses and internships have a look at the education section.
